Bühler stirred-tank reactors are the flexible workhorse for industrial biotechnology. Designed for highly controlled fermentations and cell cultures across food, feed, and industrial biotech applications, STR systems provide maximum process control from lab to large scale. With efficient gas dispersion, advanced agitation, and integrated automation, they give you the freedom to run a broad range of organisms and process modes reliably.
Precise control of mixing, pH, temperature, and dissolved oxygen for demanding fermentations and cell culture processes.
Ideal when recipes change frequently or when you run microbial, yeast, fungal, and other processes with varying oxygen demands.
Established scale-up methodologies and geometrically consistent designs from pilot volumes to industrial-scale reactors.
Bühler stirred-tank reactors are configured for your viscosity, gas load, and shear sensitivity. Agitation systems are selected and sized to match the process – from low-shear mixing for sensitive cells to intensive mixing for high-density microbial cultures. Combined sparging and mechanical mixing deliver high oxygen transfer rates and uniform conditions throughout the vessel, ensuring stable performance and consistent product quality.
Our STRs feature hygienic, CIP/SIP-ready construction with mechanical and optional electro-polished surfaces to support demanding food and pharma applications. Optional baffles, multiple impeller types, and optimized headspace design help control foaming, gas holdup, and mixing behavior. These robust designs enable reliable batch, fed-batch, and perfusion strategies that scale from development to full industrial production.
Volume ranges span from pilot systems to industrial-scale vessels (e.g. 50 L up to 100 000 L). Integrated sensors (pH, DO, temperature, level, pressure, off-gas) and Bühler automation platforms provide advanced monitoring, control, and data capture. Skid-based solutions or fully integrated process lines – including utilities, upstream preparation, and downstream processing – help you bring new bioprocesses online faster and with lower technical risk.
bioprocessing@buhlergroup.com
