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Air Lift Reactor

Bühler airlift reactors use gas injection in a riser section to drive circulation through a loop or draft tube, creating well-defined flow patterns without a mechanical agitator. This design combines low shear, good circulation, and efficient gas–liquid contact, making airlift reactors an excellent choice for sensitive organisms and energy-efficient operation.

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Key benefits

Gentle on sensitive organisms

Provides controlled circulation and mixing with significantly lower shear than strongly agitated systems, ideal for filamentous or delicate cultures.

Energy-efficient mixing

Gas-driven circulation can deliver good mixing and oxygen transfer with lower energy input than many mechanically stirred reactors.

Reliable, low-maintenance design

No internal agitator shaft – fewer seals and moving parts, reducing mechanical failures and simplifying maintenance.

Highlight features

Defined riser / downcomer circulation

Stable flow patterns for predictable performance

Airlift reactors create separate riser and downcomer zones, delivering controlled circulation and residence times. This stable, predictable flow supports consistent product quality and simplifies process optimization. Gas rate, loop geometry, and draft-tube design are engineered to balance mixing intensity, gas holdup, and shear conditions for your specific organisms and media.


Low-shear, efficient gas–liquid contact

Optimized for oxygen transfer with minimal damage

By using gas-driven circulation instead of impellers, airlift reactors maintain a low-shear environment while still achieving effective mixing and oxygen transfer. Gas distribution systems are tailored for uniform bubble formation, efficient gas utilization, and robust mass transfer. This makes airlift reactors well-suited for medium-viscosity systems and sensitive, filamentous, or shear-sensitive cultures.


Flexible loop concepts and hygienic execution

Adapted to your plant layout and automation

Bühler offers internal or external loop airlift concepts to fit your building layout and process constraints. Materials and surface finishes are selected for food and industrial biotech applications, with higher hygiene levels available on request. Integrated CIP/SIP designs ensure cleaning of all internal sections and draft tubes, while comprehensive instrumentation and Bühler automation platforms enable precise control and seamless integration with upstream and downstream operations.

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Got Questions? Let's talk.


bioprocessing@buhlergroup.com